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Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs) hemolyze more rapidly, show impaired deformability,...

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Detalles Bibliográficos
Autores principales:	Yalamanoglu, Ayla, Dubach, Irina L., Schulthess, Nadja, Ingoglia, Giada, Swindle, Delaney C., Humar, Rok, Schaer, Dominik J., Buehler, Paul W., Irwin, David C., Vallelian, Florence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982888/ https://www.ncbi.nlm.nih.gov/pubmed/33763072 http://dx.doi.org/10.3389/fimmu.2021.627944

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