Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain

Research presented here sought to determine if opioid induced tolerance is linked to activity changes within the PI3Kγ-AKT-cGMP-JNK intracellular signaling pathway in spinal cord or peripheral nervous systems. Morphine or saline injections were given subcutaneously twice a day for five days (15 mg/k...

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Detalles Bibliográficos
Autores principales: Okerman, Travis, Jurgenson, Taylor, Moore, Madelyn, Klein, Amanda H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983416/
https://www.ncbi.nlm.nih.gov/pubmed/33745380
http://dx.doi.org/10.1177/17448069211003375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983416/
https://www.ncbi.nlm.nih.gov/pubmed/33745380
http://dx.doi.org/10.1177/17448069211003375

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