Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
Severe thrombocytopenia is a rare adverse event of panitumumab. Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). A clinical diagnosis of DITP can be obtained by...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983597/ https://www.ncbi.nlm.nih.gov/pubmed/33776687 http://dx.doi.org/10.1159/000512821 |
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author | Takamizawa, Shigemasa Shoji, Hirokazu Hirano, Hidekazu Izutsu, Koji Yamamoto, Shun Iwasa, Satoru Honma, Yoshitaka Okita, Natsuko Takashima, Atsuo Kato, Ken Boku, Narikazu |
author_facet | Takamizawa, Shigemasa Shoji, Hirokazu Hirano, Hidekazu Izutsu, Koji Yamamoto, Shun Iwasa, Satoru Honma, Yoshitaka Okita, Natsuko Takashima, Atsuo Kato, Ken Boku, Narikazu |
author_sort | Takamizawa, Shigemasa |
collection | PubMed |
description | Severe thrombocytopenia is a rare adverse event of panitumumab. Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). A clinical diagnosis of DITP can be obtained by excluding other causes of thrombocytopenia and is confirmed by the recovery of thrombocytopenia after the discontinuation of the suspected drug. Treatment includes permanent discontinuation of the suspected drug. Re-exposure should be avoided. It should be kept in mind that panitumumab can induce DITP in the case of a new, sudden, unexpected, and isolated drop in platelet count after excluding other causes of thrombocytopenia. |
format | Online Article Text |
id | pubmed-7983597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-79835972021-03-26 Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer Takamizawa, Shigemasa Shoji, Hirokazu Hirano, Hidekazu Izutsu, Koji Yamamoto, Shun Iwasa, Satoru Honma, Yoshitaka Okita, Natsuko Takashima, Atsuo Kato, Ken Boku, Narikazu Case Rep Oncol Case Report Severe thrombocytopenia is a rare adverse event of panitumumab. Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). A clinical diagnosis of DITP can be obtained by excluding other causes of thrombocytopenia and is confirmed by the recovery of thrombocytopenia after the discontinuation of the suspected drug. Treatment includes permanent discontinuation of the suspected drug. Re-exposure should be avoided. It should be kept in mind that panitumumab can induce DITP in the case of a new, sudden, unexpected, and isolated drop in platelet count after excluding other causes of thrombocytopenia. S. Karger AG 2021-02-25 /pmc/articles/PMC7983597/ /pubmed/33776687 http://dx.doi.org/10.1159/000512821 Text en Copyright © 2021 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Takamizawa, Shigemasa Shoji, Hirokazu Hirano, Hidekazu Izutsu, Koji Yamamoto, Shun Iwasa, Satoru Honma, Yoshitaka Okita, Natsuko Takashima, Atsuo Kato, Ken Boku, Narikazu Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer |
title | Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer |
title_full | Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer |
title_fullStr | Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer |
title_full_unstemmed | Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer |
title_short | Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer |
title_sort | panitumumab-associated drug-induced immune thrombocytopenia in a patient with colorectal cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983597/ https://www.ncbi.nlm.nih.gov/pubmed/33776687 http://dx.doi.org/10.1159/000512821 |
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