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Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer

Severe thrombocytopenia is a rare adverse event of panitumumab. Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). A clinical diagnosis of DITP can be obtained by...

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Autores principales: Takamizawa, Shigemasa, Shoji, Hirokazu, Hirano, Hidekazu, Izutsu, Koji, Yamamoto, Shun, Iwasa, Satoru, Honma, Yoshitaka, Okita, Natsuko, Takashima, Atsuo, Kato, Ken, Boku, Narikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983597/
https://www.ncbi.nlm.nih.gov/pubmed/33776687
http://dx.doi.org/10.1159/000512821
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author Takamizawa, Shigemasa
Shoji, Hirokazu
Hirano, Hidekazu
Izutsu, Koji
Yamamoto, Shun
Iwasa, Satoru
Honma, Yoshitaka
Okita, Natsuko
Takashima, Atsuo
Kato, Ken
Boku, Narikazu
author_facet Takamizawa, Shigemasa
Shoji, Hirokazu
Hirano, Hidekazu
Izutsu, Koji
Yamamoto, Shun
Iwasa, Satoru
Honma, Yoshitaka
Okita, Natsuko
Takashima, Atsuo
Kato, Ken
Boku, Narikazu
author_sort Takamizawa, Shigemasa
collection PubMed
description Severe thrombocytopenia is a rare adverse event of panitumumab. Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). A clinical diagnosis of DITP can be obtained by excluding other causes of thrombocytopenia and is confirmed by the recovery of thrombocytopenia after the discontinuation of the suspected drug. Treatment includes permanent discontinuation of the suspected drug. Re-exposure should be avoided. It should be kept in mind that panitumumab can induce DITP in the case of a new, sudden, unexpected, and isolated drop in platelet count after excluding other causes of thrombocytopenia.
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spelling pubmed-79835972021-03-26 Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer Takamizawa, Shigemasa Shoji, Hirokazu Hirano, Hidekazu Izutsu, Koji Yamamoto, Shun Iwasa, Satoru Honma, Yoshitaka Okita, Natsuko Takashima, Atsuo Kato, Ken Boku, Narikazu Case Rep Oncol Case Report Severe thrombocytopenia is a rare adverse event of panitumumab. Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). A clinical diagnosis of DITP can be obtained by excluding other causes of thrombocytopenia and is confirmed by the recovery of thrombocytopenia after the discontinuation of the suspected drug. Treatment includes permanent discontinuation of the suspected drug. Re-exposure should be avoided. It should be kept in mind that panitumumab can induce DITP in the case of a new, sudden, unexpected, and isolated drop in platelet count after excluding other causes of thrombocytopenia. S. Karger AG 2021-02-25 /pmc/articles/PMC7983597/ /pubmed/33776687 http://dx.doi.org/10.1159/000512821 Text en Copyright © 2021 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Takamizawa, Shigemasa
Shoji, Hirokazu
Hirano, Hidekazu
Izutsu, Koji
Yamamoto, Shun
Iwasa, Satoru
Honma, Yoshitaka
Okita, Natsuko
Takashima, Atsuo
Kato, Ken
Boku, Narikazu
Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
title Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
title_full Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
title_fullStr Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
title_full_unstemmed Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
title_short Panitumumab-Associated Drug-Induced Immune Thrombocytopenia in a Patient with Colorectal Cancer
title_sort panitumumab-associated drug-induced immune thrombocytopenia in a patient with colorectal cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983597/
https://www.ncbi.nlm.nih.gov/pubmed/33776687
http://dx.doi.org/10.1159/000512821
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