Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach

BACKGROUND: Many trials of amyloid‐modulating agents fail to improve cognitive outcome in Alzheimer's disease despite substantial reduction of amyloid β levels. METHODS: We applied a mechanism‐based Quantitative Systems Pharmacology model exploring the pharmacodynamic interactions of apolipopro...

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Detalles Bibliográficos
Autores principales: Geerts, Hugo, Spiros, Athan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983876/
https://www.ncbi.nlm.nih.gov/pubmed/32255562
http://dx.doi.org/10.1002/alz.12082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983876/
https://www.ncbi.nlm.nih.gov/pubmed/32255562
http://dx.doi.org/10.1002/alz.12082

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