Clinical and Model‐Based Evaluation of the Effect of Glasdegib on Cardiac Repolarization From a Randomized Thorough QT Study

Glasdegib is a potent, selective oral inhibitor of the Hedgehog signaling pathway. This phase 1 double‐blind thorough QT study (NCT03162900) evaluated the effects of glasdegib on QTc interval. The study enrolled 36 healthy volunteers to receive a single dose of 150 mg glasdegib (representing a thera...

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Detalles Bibliográficos
Autores principales: Masters, Joanna C., Shaik, Naveed, Mendes da Costa, Laure, Hee, Brian, LaBadie, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983888/
https://www.ncbi.nlm.nih.gov/pubmed/32790066
http://dx.doi.org/10.1002/cpdd.862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983888/
https://www.ncbi.nlm.nih.gov/pubmed/32790066
http://dx.doi.org/10.1002/cpdd.862

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