Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation

Machine learning (ML) has pervaded most areas of protein engineering, including stability and stereoselectivity. Using limonene epoxide hydrolase as the model enzyme and innov'SAR as the ML platform, comprising a digital signal process, we achieved high protein robustness that can resist unfold...

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Detalles Bibliográficos
Autores principales: Li, Guangyue, Qin, Youcai, Fontaine, Nicolas T., Ng Fuk Chong, Matthieu, Maria‐Solano, Miguel A., Feixas, Ferran, Cadet, Xavier F., Pandjaitan, Rudy, Garcia‐Borràs, Marc, Cadet, Frederic, Reetz, Manfred T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984044/
https://www.ncbi.nlm.nih.gov/pubmed/33094545
http://dx.doi.org/10.1002/cbic.202000612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984044/
https://www.ncbi.nlm.nih.gov/pubmed/33094545
http://dx.doi.org/10.1002/cbic.202000612

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