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Structural Insights into the Interaction of Heme with Protein Tyrosine Kinase JAK2
Janus kinase 2 (JAK2) is the most important signal‐transducing tyrosine kinase in erythropoietic precursor cells. Its malfunction drives several myeloproliferative disorders. Heme is a small metal‐ion‐carrying molecule that is incorporated into hemoglobin in erythroid precursor cells to transport ox...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984354/ https://www.ncbi.nlm.nih.gov/pubmed/33103835 http://dx.doi.org/10.1002/cbic.202000730 |