The clinical applicability of polygenic risk scores for LDL-cholesterol: considerations, current evidence and future perspectives

The current review describes the development, clinical relevance and potential caveats of polygenic risk scores (PRS) for LDL cholesterol (LDL-C). RECENT FINDINGS: In recent years, a large number of common variants have been shown to have a small effect on LDL-C levels. The aggregate effect of all o...

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Detalles Bibliográficos
Autores principales: Cupido, Arjen J., Tromp, Tycho R., Hovingh, G. Kees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984749/
https://www.ncbi.nlm.nih.gov/pubmed/33560669
http://dx.doi.org/10.1097/MOL.0000000000000741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984749/
https://www.ncbi.nlm.nih.gov/pubmed/33560669
http://dx.doi.org/10.1097/MOL.0000000000000741

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