Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response

The RNA methyltransferase TRDMT1 has recently emerged as a key regulator of homologous recombination (HR) in the transcribed regions of the genome, but how it is regulated and its relevance in cancer remain unknown. Here, we identified that TRDMT1 is poly-ubiquitinated at K251 by the E3 ligase TRIM2...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaolan, Wang, Xiangyu, Yan, Wei, Yang, Haibo, Xiang, Yufei, Lv, Fengping, Shi, Yi, Li, Hong-yu, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984809/
https://www.ncbi.nlm.nih.gov/pubmed/33778494
http://dx.doi.org/10.1093/narcan/zcab010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984809/
https://www.ncbi.nlm.nih.gov/pubmed/33778494
http://dx.doi.org/10.1093/narcan/zcab010

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