Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcripto...

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Detalles Bibliográficos
Autores principales: Tauc, Helen M, Rodriguez-Fernandez, Imilce A, Hackney, Jason A, Pawlak, Michal, Ronnen Oron, Tal, Korzelius, Jerome, Moussa, Hagar F, Chaudhuri, Subhra, Modrusan, Zora, Edgar, Bruce A, Jasper, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984841/
https://www.ncbi.nlm.nih.gov/pubmed/33724181
http://dx.doi.org/10.7554/eLife.62250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984841/
https://www.ncbi.nlm.nih.gov/pubmed/33724181
http://dx.doi.org/10.7554/eLife.62250

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