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Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward

Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cor...

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Detalles Bibliográficos
Autores principales: Jiang, Changyou, Wang, Xueying, Le, Qiumin, Liu, Peipei, Liu, Cao, Wang, Zhilin, He, Guanhong, Zheng, Ping, Wang, Feifei, Ma, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985023/
https://www.ncbi.nlm.nih.gov/pubmed/31413370
http://dx.doi.org/10.1038/s41380-019-0480-7