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Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations

Cancer is a critical health burden in Africa, and mortality rates are rising rapidly. Treatments are expensive and often cause adverse drug reactions (ADRs). Fluoropyrimidine treatments can lead to severe toxicity events which have been linked to variants within the dihydropyrimidine dehydrogenase (...

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Detalles Bibliográficos
Autores principales:	da Rocha, Jorge E. B., Lombard, Zané, Ramsay, Michèle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985174/ https://www.ncbi.nlm.nih.gov/pubmed/33767731 http://dx.doi.org/10.3389/fgene.2021.626954

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