PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis

Patients infected by Leishmania braziliensis develop debilitating skin lesions. The role of inhibitory checkpoint receptors (ICRs) that induce T cell exhaustion during this disease is not known. Transcriptional profiling identified increased expression of ICRs including PD-1, PDL-1, PDL-2, TIM-3, an...

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Detalles Bibliográficos
Autores principales: Garcia de Moura, Renan, Covre, Luciana Polaco, Fantecelle, Carlos Henrique, Gajardo, Vitor Alejandro Torres, Cunha, Carla Baroni, Stringari, Lorenzzo Lyrio, Belew, Ashton Trey, Daniel, Camila Batista, Zeidler, Sandra Ventorin Von, Tadokoro, Carlos Eduardo, de Matos Guedes, Herbert Leonel, Zanotti, Raphael Lubiana, Mosser, David, Falqueto, Aloisio, Akbar, Arne N., Gomes, Daniel Claudio Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985249/
https://www.ncbi.nlm.nih.gov/pubmed/33767700
http://dx.doi.org/10.3389/fimmu.2021.632667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985249/
https://www.ncbi.nlm.nih.gov/pubmed/33767700
http://dx.doi.org/10.3389/fimmu.2021.632667

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