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Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome

BACKGROUND: The mechanism of Brugada syndrome (BrS) is still unclear, with different researchers favoring either the repolarization or depolarization hypothesis. Prolonged longitudinal activation time has been verified in only a small number of human right ventricles (RVs). The purpose of the presen...

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Autores principales: Yoon, Namsik, Jeong, Hyung Ki, Lee, Ki Hong, Park, Hyung Wook, Cho, Jeong Gwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985285/
https://www.ncbi.nlm.nih.gov/pubmed/33754508
http://dx.doi.org/10.3346/jkms.2021.36.e75
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author Yoon, Namsik
Jeong, Hyung Ki
Lee, Ki Hong
Park, Hyung Wook
Cho, Jeong Gwan
author_facet Yoon, Namsik
Jeong, Hyung Ki
Lee, Ki Hong
Park, Hyung Wook
Cho, Jeong Gwan
author_sort Yoon, Namsik
collection PubMed
description BACKGROUND: The mechanism of Brugada syndrome (BrS) is still unclear, with different researchers favoring either the repolarization or depolarization hypothesis. Prolonged longitudinal activation time has been verified in only a small number of human right ventricles (RVs). The purpose of the present study was to demonstrate RV conduction delays in BrS. METHODS: The RV outflow tract (RVOT)-to-RV apex (RVA) and RVA-to-RVOT conduction times were measured by endocardial stimulation and mapping in 7 patients with BrS and 14 controls. RESULTS: Patients with BrS had a longer PR interval (180 ± 12.6 vs. 142 ± 6.7 ms, P = 0.016). The RVA-to-RVOT conduction time was longer in the patients with BrS than in controls (stimulation at 600 ms, 107 ± 9.9 vs. 73 ± 3.4 ms, P = 0.001; stimulation at 500 ms, 104 ± 12.3 vs. 74 ± 4.2 ms, P = 0.037; stimulation at 400 ms, 107 ±12.2 vs. 73 ± 5.1 ms, P = 0.014). The RVOT-to-RVA conduction time was longer in the patients with BrS than in controls (stimulation at 500 ms, 95 ± 10.3 vs. 62 ± 4.1 ms, P = 0.007; stimulation at 400 ms, 94 ±11.2 vs. 64 ± 4.6 ms, P = 0.027). The difference in longitudinal conduction time was not significant when isoproterenol was administered. CONCLUSION: The patients with BrS showed an RV longitudinal conduction delay obviously. These findings suggest that RV conduction delay might contribute to generate the BrS phenotype.
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spelling pubmed-79852852021-03-31 Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome Yoon, Namsik Jeong, Hyung Ki Lee, Ki Hong Park, Hyung Wook Cho, Jeong Gwan J Korean Med Sci Original Article BACKGROUND: The mechanism of Brugada syndrome (BrS) is still unclear, with different researchers favoring either the repolarization or depolarization hypothesis. Prolonged longitudinal activation time has been verified in only a small number of human right ventricles (RVs). The purpose of the present study was to demonstrate RV conduction delays in BrS. METHODS: The RV outflow tract (RVOT)-to-RV apex (RVA) and RVA-to-RVOT conduction times were measured by endocardial stimulation and mapping in 7 patients with BrS and 14 controls. RESULTS: Patients with BrS had a longer PR interval (180 ± 12.6 vs. 142 ± 6.7 ms, P = 0.016). The RVA-to-RVOT conduction time was longer in the patients with BrS than in controls (stimulation at 600 ms, 107 ± 9.9 vs. 73 ± 3.4 ms, P = 0.001; stimulation at 500 ms, 104 ± 12.3 vs. 74 ± 4.2 ms, P = 0.037; stimulation at 400 ms, 107 ±12.2 vs. 73 ± 5.1 ms, P = 0.014). The RVOT-to-RVA conduction time was longer in the patients with BrS than in controls (stimulation at 500 ms, 95 ± 10.3 vs. 62 ± 4.1 ms, P = 0.007; stimulation at 400 ms, 94 ±11.2 vs. 64 ± 4.6 ms, P = 0.027). The difference in longitudinal conduction time was not significant when isoproterenol was administered. CONCLUSION: The patients with BrS showed an RV longitudinal conduction delay obviously. These findings suggest that RV conduction delay might contribute to generate the BrS phenotype. The Korean Academy of Medical Sciences 2021-03-08 /pmc/articles/PMC7985285/ /pubmed/33754508 http://dx.doi.org/10.3346/jkms.2021.36.e75 Text en © 2021 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Namsik
Jeong, Hyung Ki
Lee, Ki Hong
Park, Hyung Wook
Cho, Jeong Gwan
Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome
title Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome
title_full Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome
title_fullStr Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome
title_full_unstemmed Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome
title_short Right Ventricular Longitudinal Conduction Delay in Patients with Brugada Syndrome
title_sort right ventricular longitudinal conduction delay in patients with brugada syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985285/
https://www.ncbi.nlm.nih.gov/pubmed/33754508
http://dx.doi.org/10.3346/jkms.2021.36.e75
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