A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not reproducibly grow in xenografts without manipulation...

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Detalles Bibliográficos
Autores principales: Patten, Piers E. M., Ferrer, Gerardo, Chen, Shih-Shih, Kolitz, Jonathan E., Rai, Kanti R., Allen, Steven L., Barrientos, Jacqueline C., Ioannou, Nikolaos, Ramsay, Alan G., Chiorazzi, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985329/
https://www.ncbi.nlm.nih.gov/pubmed/33767698
http://dx.doi.org/10.3389/fimmu.2021.627020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985329/
https://www.ncbi.nlm.nih.gov/pubmed/33767698
http://dx.doi.org/10.3389/fimmu.2021.627020

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