Cargando…

A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not reproducibly grow in xenografts without manipulation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patten, Piers E. M., Ferrer, Gerardo, Chen, Shih-Shih, Kolitz, Jonathan E., Rai, Kanti R., Allen, Steven L., Barrientos, Jacqueline C., Ioannou, Nikolaos, Ramsay, Alan G., Chiorazzi, Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985329/ https://www.ncbi.nlm.nih.gov/pubmed/33767698 http://dx.doi.org/10.3389/fimmu.2021.627020

Ejemplares similares

Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target
por: Palacios, Florencia, et al.
Publicado: (2021)

Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes
por: Sherry, Barbara, et al.
Publicado: (2015)

Characterization of the Intraclonal Complexity of Chronic Lymphocytic Leukemia B Cells: Potential Influences of B-Cell Receptor Crosstalk with Other Stimuli
por: Mazzarello, Andrea N., et al.
Publicado: (2023)

Targeting the tumor microenvironment in chronic lymphocytic leukemia
por: Svanberg, Rebecka, et al.
Publicado: (2021)

Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia
por: Messmer, Bradley T., et al.
Publicado: (2004)

Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
por: Bagnara, Davide, et al.
Publicado: (2021)

FcγRIIb-BCR coligation inhibits B-cell receptor signaling in chronic lymphocytic leukemia
por: Bosch, Rosa, et al.
Publicado: (2020)

Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL
por: Ferrer, Gerardo, et al.
Publicado: (2021)

Chylothorax in Patients With Chronic Lymphocytic Leukemia: A Case Series
por: Sammartino, Daniel, et al.
Publicado: (2018)

Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia
por: Kaufman, Matthew, et al.
Publicado: (2022)

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia
por: Murphy, Elizabeth J., et al.
Publicado: (2017)

Correction to: Intraclonal Complexity in Chronic Lymphocytic Leukemia: Fractions Enriched in Recently Born/Divided and Older/Quiescent Cells
por: Calissano, Carlo, et al.
Publicado: (2022)

Cytoplasmic myosin exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability
por: Cui, Xiaoxuan, et al.
Publicado: (2015)

Overview of recent developments in chronic lymphocytic leukemia
por: Jain, Preetesh, et al.
Publicado: (2012)

B cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia
por: Mazzarello, Andrea N., et al.
Publicado: (2022)

Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin V(H)DJ(H) Gene Diversification
por: Gurrieri, Carmela, et al.
Publicado: (2002)

Renal involvement in chronic lymphocytic leukemia
por: Wanchoo, Rimda, et al.
Publicado: (2018)

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression
por: Oppezzo, Pablo, et al.
Publicado: (2021)

Idelalisib in Combination With Rituximab or Bendamustine or Both in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia
por: Coutre, Steven E., et al.
Publicado: (2018)

Therapeutic potential of new B cell-targeted agents in the treatment of elderly and unfit patients with chronic lymphocytic leukemia
por: Rai, Kanti R.
Publicado: (2015)

Immunoglobulin replacement therapy targeting the BCR in chronic lymphocytic leukemia
por: Ferrer, Gerardo
Publicado: (2018)

Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups
por: Decker, Sarah, et al.
Publicado: (2019)

A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells
por: Yigit, Burcu, et al.
Publicado: (2016)

In vitro and in vivo evidence for uncoupling of B-cell receptor internalization and signaling in chronic lymphocytic leukemia
por: Coulter, Eve M., et al.
Publicado: (2018)

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia
por: Chen, S-S, et al.
Publicado: (2016)

Oral PI3K-δ,γ Inhibitor for the Management of People with Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Narrative Review on Duvelisib
por: Shah, Ankit, et al.
Publicado: (2021)

CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring
por: Vergani, Stefano, et al.
Publicado: (2023)

Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
por: Malcikova, J, et al.
Publicado: (2015)

Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells
por: Krevvata, Maria, et al.
Publicado: (2018)

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy
por: Arruga, Francesca, et al.
Publicado: (2023)

Multiplex accurate sensitive quantitation (MASQ) with application to minimal residual disease in acute myeloid leukemia
por: Moffitt, Andrea B, et al.
Publicado: (2020)

Case report: Successful treatment of refractory immune thrombocytopenia in chronic lymphocytic leukaemia with venetoclax monotherapy
por: Woo, Timothy, et al.
Publicado: (2023)

Through the Looking Glass: Visualizing Leukemia Growth, Migration, and Engraftment Using Fluorescent Transgenic Zebrafish
por: Moore, Finola E., et al.
Publicado: (2012)

The Engrafting of Nerves
Publicado: (1845)

Ibrutinib Plus Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia: The CLARITY Study
por: Hillmen, Peter, et al.
Publicado: (2019)

The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia
por: Yuan, Chaohui, et al.
Publicado: (2017)

Characteristics and Clinical Outcomes of Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Receiving Ibrutinib for ≥5 Years in the RESONATE-2 Study
por: Woyach, Jennifer A., et al.
Publicado: (2023)

Interleukin-27 potentiates CD8(+) T-cell-mediated antitumor immunity in chronic lymphocytic leukemia
por: Pagano, Giulia, et al.
Publicado: (2023)

Detailed safety profile of acalabrutinib vs ibrutinib in previously treated chronic lymphocytic leukemia in the ELEVATE-RR trial
por: Seymour, John F., et al.
Publicado: (2023)

Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy
por: Gopalakrishnapillai, Anilkumar, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cbnv91o398e9n83t17j3accli9