Computational Design of gRNAs Targeting Genetic Variants Across HIV-1 Subtypes for CRISPR-Mediated Antiviral Therapy

Clustered regularly interspaced short palindromic repeats (CRISPR)-based HIV-1 genome editing has shown promising outcomes in in vitro and in vivo viral infection models. However, existing HIV-1 sequence variants have been shown to reduce CRISPR-mediated efficiency and induce viral escape. Two metri...

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Detalles Bibliográficos
Autores principales: Chung, Cheng-Han, Allen, Alexander G., Atkins, Andrew, Link, Robert W., Nonnemacher, Michael R., Dampier, Will, Wigdahl, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985454/
https://www.ncbi.nlm.nih.gov/pubmed/33768011
http://dx.doi.org/10.3389/fcimb.2021.593077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985454/
https://www.ncbi.nlm.nih.gov/pubmed/33768011
http://dx.doi.org/10.3389/fcimb.2021.593077

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