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Computational Design of gRNAs Targeting Genetic Variants Across HIV-1 Subtypes for CRISPR-Mediated Antiviral Therapy

Clustered regularly interspaced short palindromic repeats (CRISPR)-based HIV-1 genome editing has shown promising outcomes in in vitro and in vivo viral infection models. However, existing HIV-1 sequence variants have been shown to reduce CRISPR-mediated efficiency and induce viral escape. Two metri...

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Detalles Bibliográficos
Autores principales:	Chung, Cheng-Han, Allen, Alexander G., Atkins, Andrew, Link, Robert W., Nonnemacher, Michael R., Dampier, Will, Wigdahl, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985454/ https://www.ncbi.nlm.nih.gov/pubmed/33768011 http://dx.doi.org/10.3389/fcimb.2021.593077

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