The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key characteristic of Parkinson’s disease. To define the nature of the species giving rise to neuronal damage, we have investigated the mechanism of action of the main αS populations that have been observed to form progre...

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Detalles Bibliográficos
Autores principales: Cascella, Roberta, Chen, Serene W., Bigi, Alessandra, Camino, José D., Xu, Catherine K., Dobson, Christopher M., Chiti, Fabrizio, Cremades, Nunilo, Cecchi, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985515/
https://www.ncbi.nlm.nih.gov/pubmed/33753734
http://dx.doi.org/10.1038/s41467-021-21937-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985515/
https://www.ncbi.nlm.nih.gov/pubmed/33753734
http://dx.doi.org/10.1038/s41467-021-21937-3

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