Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

The pathogenesis of Alzheimer's disease (AD) is correlated with the misfolding and aggregation of amyloid-beta protein (Aβ). Here we report that the antibiotic benzylpenicillin (BP) can specifically bind to Aβ, modulate the process of aggregation and supress its cytotoxic effect, initially via...

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Detalles Bibliográficos
Autores principales: Alsalahat, Izzeddin, Al-Majdoub, Zubida M., Taha, Mutasem O., Barber, Jill, Aojula, Harmesh, Hodson, Nigel, Freeman, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985693/
https://www.ncbi.nlm.nih.gov/pubmed/33778168
http://dx.doi.org/10.1016/j.bbrep.2021.100943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985693/
https://www.ncbi.nlm.nih.gov/pubmed/33778168
http://dx.doi.org/10.1016/j.bbrep.2021.100943

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