Structure-based inhibitor screening of natural products against NSP15 of SARS-CoV-2 revealed thymopentin and oleuropein as potent inhibitors

Coronaviruses are enveloped, non-segmented positive-sense RNA viruses with the largest genome among RNA viruses. Their genome contains a large replicase ORF which encodes nonstructural proteins (NSPs), structural, and accessory genes. NSP15 is a nidoviral RNA uridylate-specific endoribonuclease (Nen...

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Detalles Bibliográficos
Autores principales: Vijayan, Ramachandran, Gourinath, Samudrala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985738/
https://www.ncbi.nlm.nih.gov/pubmed/33776343
http://dx.doi.org/10.1007/s42485-021-00059-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985738/
https://www.ncbi.nlm.nih.gov/pubmed/33776343
http://dx.doi.org/10.1007/s42485-021-00059-w

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