Cargando…

Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells

Most metallodrugs are prodrugs that can undergo ligand exchange and redox reactions in biological media. Here we have investigated the cellular stability of the anticancer complex [Os(II)[(η(6)‐p‐cymene)(RR/SS‐MePh‐DPEN)] [1] (MePh‐DPEN=tosyl‐diphenylethylenediamine) which catalyses the enantioselec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bolitho, Elizabeth M., Coverdale, James P. C., Bridgewater, Hannah E., Clarkson, Guy J., Quinn, Paul D., Sanchez‐Cano, Carlos, Sadler, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985874/ https://www.ncbi.nlm.nih.gov/pubmed/33590607 http://dx.doi.org/10.1002/anie.202016456

Ejemplares similares

Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
por: Coverdale, James P. C., et al.
Publicado: (2015)

In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes
por: Needham, Russell J., et al.
Publicado: (2016)

Osmium–arene complexes with high potency towards Mycobacterium tuberculosis
por: Coverdale, James P C, et al.
Publicado: (2021)

NMR studies of group 8 metallodrugs: (187)Os-enriched organo-osmium half-sandwich anticancer complex
por: Needham, Russell J., et al.
Publicado: (2021)

Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors
por: Bridgewater, Hannah E., et al.
Publicado: (2023)

Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice
por: Kumar, Swati A, et al.
Publicado: (2020)

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts
por: Chen, Feng, et al.
Publicado: (2018)

Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells
por: Sanchez‐Cano, Carlos, et al.
Publicado: (2017)

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
por: Coverdale, James P. C., et al.
Publicado: (2018)

Ligand-centred redox activation of inert organoiridium anticancer catalysts
por: Zhang, Wen-Ying, et al.
Publicado: (2020)

Organo-Nanocups Assist the Formation of Ultra-Small Palladium Nanoparticle Catalysts for Hydrogen Evolution Reaction
por: Biehler, Erik, et al.
Publicado: (2022)

Sulfone Group as a Versatile and Removable Directing Group for Asymmetric Transfer Hydrogenation of Ketones
por: Vyas, Vijyesh K., et al.
Publicado: (2020)

Mechanistic Complexity of Asymmetric Transfer Hydrogenation with Simple Mn–Diamine Catalysts
por: van Putten, Robbert, et al.
Publicado: (2019)

Rational Optimization of Supramolecular Catalysts for the Rhodium‐Catalyzed Asymmetric Hydrogenation Reaction
por: Daubignard, Julien, et al.
Publicado: (2017)

Physicochemical Properties of Mesoporous Organo-Silica Xerogels Fabricated through Organo Catalyst
por: Elma, Muthia, et al.
Publicado: (2021)

Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity
por: Gatti, Anna, et al.
Publicado: (2018)

Halide Control of N,N-Coordination versus N,C-Cyclometalation and Stereospecific Phenyl Ring Deuteration of Osmium(II) p-Cymene Phenylazobenzothiazole Complexes
por: Needham, Russell J., et al.
Publicado: (2017)

Mirror-Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity
por: Fu, Ying, et al.
Publicado: (2013)

Organo-niobate Ionic Liquids: Synthesis, Characterization and Application as Acid Catalyst in Pechmann Reactions
por: Soares, Valerio C. D., et al.
Publicado: (2007)

Does the Configuration at the Metal Matter in Noyori–Ikariya Type Asymmetric Transfer Hydrogenation Catalysts?
por: Hall, Andrew M. R., et al.
Publicado: (2021)

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis
por: Hack, Daniel, et al.
Publicado: (2016)

Osmium(ii) tethered half-sandwich complexes: pH-dependent aqueous speciation and transfer hydrogenation in cells
por: Infante-Tadeo, Sonia, et al.
Publicado: (2021)

Reactional Processes on Osmium–Polymeric Membranes for 5–Nitrobenzimidazole Reduction
por: Nechifor, Aurelia Cristina, et al.
Publicado: (2021)

Ruthenacycles and Iridacycles as Transfer Hydrogenation Catalysts
por: Ritleng, Vincent, et al.
Publicado: (2021)

Amino Acylguanidines as Bioinspired Catalysts for the Asymmetric Aldol Reaction
por: Jimeno, Ciril
Publicado: (2021)

Alternative Conceptual Approach to the Design of Bifunctional Catalysts: An Osmium Germylene System for the Dehydrogenation of Formic Acid
por: Buil, María L., et al.
Publicado: (2021)

Pentaphosphaferrocene-mediated synthesis of asymmetric organo-phosphines starting from white phosphorus
por: Reichl, Stephan, et al.
Publicado: (2021)

Asymmetric Ruthenium(II) and Osmium(II) Complexes with New Bidentate Polyquinoline Ligands. Synthesis and NMR Characterization
por: Mamo, Antonino, et al.
Publicado: (2010)

Repercussion of a 1,3-Hydrogen Shift in a Hydride-Osmium-Allenylidene Complex
por: Esteruelas, Miguel A., et al.
Publicado: (2021)

Osmium: An Appraisal of Environmental Exposure
por: Smith, Ivan C., et al.
Publicado: (1974)

Vapor Pressures of Ruthenium and Osmium
por: Carrera, N. J., et al.
Publicado: (1964)

Injections of Osmium Acid in Neuralgia
Publicado: (1886)

Asymmetric cyclopropanation of chalcones using chiral phase-transfer catalysts
por: Herchl, Richard, et al.
Publicado: (2013)

Transfer hydrogenation catalysis in cells
por: Banerjee, Samya, et al.
Publicado: (2020)

A CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC STUDY OF THE PRODUCTS OF THE REACTION OF OSMIUM TETROXIDE WITH UNSATURATED LIPIDS
por: Korn, Edward D.
Publicado: (1967)

The Implications of the Brønsted Acidic Properties of Crabtree-Type Catalysts in the Asymmetric Hydrogenation of Olefins
por: Peters, Bram B. C., et al.
Publicado: (2022)

Actin filament destruction by osmium tetroxide
Publicado: (1978)

Hydrogen Transfer-Mediated Multicomponent Reaction for Direct Synthesis of Quinazolines by a Naphthyridine-Based Iridium Catalyst
por: Tan, Zhenda, et al.
Publicado: (2020)

Enantioselective Total Synthesis of (−)‐Finerenone Using Asymmetric Transfer Hydrogenation
por: Lerchen, Andreas, et al.
Publicado: (2020)

Opportunities Offered by Chiral η(6)-Arene/N-Arylsulfonyl-diamine-Ru(II) Catalysts in the Asymmetric Transfer Hydrogenation of Ketones and Imines
por: Václavík, Jiří, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lm9reci03dtnkg28al623uns1f