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Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts
Conflicts between the replication and transcription machineries have profound effects on chromosome duplication, genome organization, and evolution across species. Head-on conflicts (lagging-strand genes) are significantly more detrimental than codirectional conflicts (leading-strand genes). The fun...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986047/ https://www.ncbi.nlm.nih.gov/pubmed/33657379 http://dx.doi.org/10.1016/j.celrep.2021.108797 |