Replacing the Rhamnose‐Xylose Moiety of QS‐21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Adjuvants are key immunostimulatory components in vaccine formulations, which improve the immune response to the co‐administered antigen. The saponin natural product QS‐21 is one of the most promising immunoadjuvants in the development of vaccines against cancer and infectious diseases but suffers f...

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Detalles Bibliográficos
Autores principales: Fuentes, Roberto, Ruiz‐de‐Angulo, Ane, Sacristán, Nagore, Navo, Claudio Daniel, Jiménez‐Osés, Gonzalo, Anguita, Juan, Fernández‐Tejada, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986102/
https://www.ncbi.nlm.nih.gov/pubmed/33236801
http://dx.doi.org/10.1002/chem.202004705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986102/
https://www.ncbi.nlm.nih.gov/pubmed/33236801
http://dx.doi.org/10.1002/chem.202004705

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