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Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function
Primary cilia are small microtubule‐based organelles capable of transducing signals from growth factor receptors embedded in the cilia membrane. Developmentally, oligodendrocyte progenitor cells (OPCs) express genes associated with primary cilia assembly, disassembly, and signaling, however, the imp...
Autores principales: | Cullen, Carlie L., O'Rourke, Megan, Beasley, Shannon J., Auderset, Loic, Zhen, Yilan, Pepper, Renee E., Gasperini, Robert, Young, Kaylene M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986221/ https://www.ncbi.nlm.nih.gov/pubmed/33368703 http://dx.doi.org/10.1002/glia.23957 |
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