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Systemic and topical administration of spermidine accelerates skin wound healing

BACKGROUND: The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA receptor (uPAR) signaling in vitro. Here, we inve...

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Detalles Bibliográficos
Autores principales: Ito, Daisuke, Ito, Hiroyasu, Ideta, Takayasu, Kanbe, Ayumu, Ninomiya, Soranobu, Shimizu, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986284/
https://www.ncbi.nlm.nih.gov/pubmed/33752688
http://dx.doi.org/10.1186/s12964-021-00717-y