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Nonlinear ridge regression improves cell-type-specific differential expression analysis

BACKGROUND: Epigenome-wide association studies (EWAS) and differential gene expression analyses are generally performed on tissue samples, which consist of multiple cell types. Cell-type-specific effects of a trait, such as disease, on the omics expression are of interest but difficult or costly to...

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Detalles Bibliográficos
Autores principales: Takeuchi, Fumihiko, Kato, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986289/
https://www.ncbi.nlm.nih.gov/pubmed/33752591
http://dx.doi.org/10.1186/s12859-021-03982-3