Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

The increasing prevalence of metallo‐β‐lactamase (MBL)‐expressing bacteria presents a worrying trend in antibiotic resistance. MBLs rely on active site zinc ions for their hydrolytic activity and the pursuit of MBL‐inhibitors has therefore involved the investigation of zinc chelators. To ensure that...

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Detalles Bibliográficos
Autores principales: van Haren, Matthijs J., Tehrani, Kamaleddin H. M. E., Kotsogianni, Ioli, Wade, Nicola, Brüchle, Nora C., Mashayekhi, Vida, Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986777/
https://www.ncbi.nlm.nih.gov/pubmed/33237604
http://dx.doi.org/10.1002/chem.202004694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986777/
https://www.ncbi.nlm.nih.gov/pubmed/33237604
http://dx.doi.org/10.1002/chem.202004694

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