Cargando…
ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease
We propose the altered lipidostasis hypothesis of Alzheimer's disease (AD). It holds that vulnerable neurons of the entorhinal region generate a neurodegenerative lipid during normal function, adenosine triphosphate–binding cassette transporter subfamily A member 7 (ABCA7) protects from AD path...
Autores principales: | Lyssenko, Nicholas N., Praticò, Domenico |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986801/ https://www.ncbi.nlm.nih.gov/pubmed/33336544 http://dx.doi.org/10.1002/alz.12220 |
Ejemplares similares
-
Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA
por: Wiener, Joel P., et al.
Publicado: (2023) -
MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis
por: Lee, Dongyeop, et al.
Publicado: (2019) -
ABCA7 and Pathogenic Pathways of Alzheimer’s Disease
por: Aikawa, Tomonori, et al.
Publicado: (2018) -
Role of ABCA7 in Human Health and in Alzheimer’s Disease
por: Dib, Shiraz, et al.
Publicado: (2021) -
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
por: Arnsten, Amy F. T., et al.
Publicado: (2020)