TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non‐CpG sites in pseudogene templates

Diversification of the avian primary immunoglobulin (Ig) repertoire is achieved in developing B cells by somatic hypermutation (SHM) and gene conversion (GCV). GCV is a type of homologous recombination that unidirectionally transfers segments of Ig pseudogenes to Ig variable domains. It is regulated...

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Detalles Bibliográficos
Autores principales: Takamura, Natsuki, Seo, Hidetaka, Ohta, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986818/
https://www.ncbi.nlm.nih.gov/pubmed/33421268
http://dx.doi.org/10.1111/gtc.12828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986818/
https://www.ncbi.nlm.nih.gov/pubmed/33421268
http://dx.doi.org/10.1111/gtc.12828

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