Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study

Interleukin-7 (IL-7) signaling modulates T cell activity and is implicated in numerous autoimmune diseases. An anti-IL-7 receptor monoclonal antibody (GSK2618960) biotherapeutic was evaluated in healthy subjects for safety, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity in a single-...

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Detalles Bibliográficos
Autores principales: Liao, Karen, Chen, Keguan, Brett, Sara, Gehman, Andrew, Schwartz, Ann M., Gunn, George R., DeWall, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987154/
https://www.ncbi.nlm.nih.gov/pubmed/33755713
http://dx.doi.org/10.1371/journal.pone.0249049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987154/
https://www.ncbi.nlm.nih.gov/pubmed/33755713
http://dx.doi.org/10.1371/journal.pone.0249049

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