Cargando…

Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study

Interleukin-7 (IL-7) signaling modulates T cell activity and is implicated in numerous autoimmune diseases. An anti-IL-7 receptor monoclonal antibody (GSK2618960) biotherapeutic was evaluated in healthy subjects for safety, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity in a single-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Karen, Chen, Keguan, Brett, Sara, Gehman, Andrew, Schwartz, Ann M., Gunn, George R., DeWall, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987154/ https://www.ncbi.nlm.nih.gov/pubmed/33755713 http://dx.doi.org/10.1371/journal.pone.0249049

Ejemplares similares

Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study
por: Ellis, Joanne, et al.
Publicado: (2018)

Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects
por: Tompson, Debra J., et al.
Publicado: (2020)

A Phase 1 study of the long‐acting anti‐IL‐5 monoclonal antibody GSK3511294 in patients with asthma
por: Singh, Dave, et al.
Publicado: (2021)

A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus
por: McKie, Elizabeth A., et al.
Publicado: (2016)

Does transcranial direct current stimulation to the prefrontal cortex affect social behavior? A meta-analysis
por: Bell, Sarah Beth, et al.
Publicado: (2018)

The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects
por: Ziauddeen, Hisham, et al.
Publicado: (2013)

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects
por: Miller, Bruce E., et al.
Publicado: (2015)

Monoclonal antibodies: Impaired humoral immunity: 5 case reports
Publicado: (2020)

Humor as a Reward Mechanism: Event-Related Potentials in the Healthy and Diseased Brain
por: Mensen, Armand, et al.
Publicado: (2014)

731. Pharmacokinetics of Gepotidacin (GSK2140944) in Subjects with Hepatic Impairment
por: Hands, Jonathan T, et al.
Publicado: (2019)

Pharmacokinetics and pharmacodynamics of mepolizumab, an anti–interleukin 5 monoclonal antibody, in healthy Japanese male subjects
por: Tsukamoto, Naohiro, et al.
Publicado: (2015)

Proof-of-Concept Randomized Trial of the Monoclonal Antibody GSK249320 Versus Placebo in Stroke Patients
por: Cramer, Steven C., et al.
Publicado: (2017)

Increased levels of IL-6, sIL-6R, and sgp130 in the aqueous humor and serum of patients with diabetic retinopathy
por: Chen, Hui, et al.
Publicado: (2016)

A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function
por: Wlodek, E., et al.
Publicado: (2021)

The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects
por: Johnson, Mark, et al.
Publicado: (2018)

In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys
por: Aweda, Tolulope A., et al.
Publicado: (2022)

Integration of Cellular and Humoral Immune Responses as an Immunomonitoring Tool for SARS-CoV-2 Vaccination in Healthy and Fragile Subjects
por: Brisotto, Giulia, et al.
Publicado: (2023)

Population Pharmacodynamic Analyses of Human Anti-Rabies Virus Monoclonal Antibody (Ormutivimab) in Healthy Adult Subjects
por: Zhang, Junnan, et al.
Publicado: (2022)

The optimal calibration hypothesis: how life history modulates the brain's social pain network
por: Chester, David S., et al.
Publicado: (2012)

Variability in PCB and OH-PCB Serum Levels in Children and Their Mothers in Urban and Rural U.S. Communities
por: Marek, Rachel F., et al.
Publicado: (2014)

Neural mechanisms of the rejection–aggression link
por: Chester, David S, et al.
Publicado: (2018)

Assessment of salivary and gingival crevicular fluids IL6, IL-8, IL-12, and IL-17 levels in healthy subjects and patients with periodontal disease
por: Majeed, Zeyad N., et al.
Publicado: (2023)

Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated
por: Maaske, Jill, et al.
Publicado: (2023)

Robust hepatitis B vaccine-reactive T cell responses in failed humoral immunity
por: Awad, Gounwa, et al.
Publicado: (2021)

1115. Evaluation of Gepotidacin (GSK2140944) Pharmacokinetics and Food Effect in Japanese Subjects
por: Hossain, Mohammad, et al.
Publicado: (2021)

Absence of Herpesvirus DNA in Aqueous Humor from Asymptomatic Subjects
por: von Hofsten, Joanna, et al.
Publicado: (2022)

fNIRS can robustly measure brain activity during memory encoding and retrieval in healthy subjects
por: Jahani, Sahar, et al.
Publicado: (2017)

Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis
por: Li, Qian, et al.
Publicado: (2022)

Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitor [(18)F]GSK2647544 in Healthy Male Subjects
por: Huiban, Mickael, et al.
Publicado: (2016)

Robust humoral immune response after boosting in children with Multisystem Inflammatory Syndrome in Children
por: Chang, Arthur J., et al.
Publicado: (2022)

Humoral Immunity in Immunosuppressed IBD Patients after the Third SARS-CoV-2 Vaccination: A Comparison with Healthy Control Subjects
por: Vollenberg, Richard, et al.
Publicado: (2023)

Prediction of effective humoral response to SARS-CoV-2 vaccines in healthy subjects by cortical thickness of post-vaccination reactive lymphadenopathy
por: Igual-Rouilleault, Alba Cristina, et al.
Publicado: (2023)

hIL‐7‐hyFc, A Long‐Acting IL‐7, Increased Absolute Lymphocyte Count in Healthy Subjects
por: Lee, Sang Won, et al.
Publicado: (2020)

Effect of Religiosity and Dysfunctional Dating Attitudes on Youth Substance Use
por: Tharp, Andra Teten, et al.
Publicado: (2014)

The Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GSK1322322 in Healthy Volunteers
por: Naderer, Odin, et al.
Publicado: (2015)

Pharmacokinetic, Safety, and Tolerability Evaluations of Gepotidacin (GSK2140944) in Healthy Japanese Participants
por: Barth, Aline, et al.
Publicado: (2022)

Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
por: Park, Jisuk, et al.
Publicado: (2019)

Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4
Publicado: (1986)

THU534 Humoral Hypercalcemia Of Malignancy As Initial Presentation Of Hepatocellular Carcinoma And Monoclonal Gammopathy Of Undetermined Significance
por: Jovanovic, Filip, et al.
Publicado: (2023)

GSK3β inhibition attenuates LPS-induced IL-6 expression in porcine adipocytes
por: Wang, Linjie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_r79da4t5q03mrcm98o75fli9r4