Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing the ISR can improve remyelination in an infla...

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Detalles Bibliográficos
Autores principales: Chen, Yanan, Kunjamma, Rejani B, Weiner, Molly, Chan, Jonah R, Popko, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987340/
https://www.ncbi.nlm.nih.gov/pubmed/33752802
http://dx.doi.org/10.7554/eLife.65469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987340/
https://www.ncbi.nlm.nih.gov/pubmed/33752802
http://dx.doi.org/10.7554/eLife.65469

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