CRISPR/Cas-Dependent and Nuclease-Free In Vivo Therapeutic Gene Editing

Precise gene manipulation by gene editing approaches facilitates the potential to cure several debilitating genetic disorders. Gene modification stimulated by engineered nucleases induces a double-stranded break (DSB) in the target genomic locus, thereby activating DNA repair mechanisms. DSBs trigge...

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Detalles Bibliográficos
Autores principales: Dasgupta, Ishani, Flotte, Terence R., Keeler, Allison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987363/
https://www.ncbi.nlm.nih.gov/pubmed/33750221
http://dx.doi.org/10.1089/hum.2021.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987363/
https://www.ncbi.nlm.nih.gov/pubmed/33750221
http://dx.doi.org/10.1089/hum.2021.013

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