H(2)O(2)-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways

Mn(III) ortho-N-alkyl- and N-alkoxyalkyl porphyrins (MnPs) were initially developed as superoxide dismutase (SOD) mimics. These compounds were later shown to react with numerous reactive species (such as ONOO(−), H(2)O(2), H(2)S, CO(3)(•-), ascorbate, and GSH). Moreover, the ability of MnPs to oxida...

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Bibliographic Details
Main Authors: Batinic-Haberle, Ines, Tovmasyan, Artak, Huang, Zhiqing, Duan, Weina, Du, Li, Siamakpour-Reihani, Sharareh, Cao, Zhipeng, Sheng, Huaxin, Spasojevic, Ivan, Alvarez Secord, Angeles
Format: Online Article Text
Language:English
Published: Hindawi 2021
Subjects:
Review Article
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987459/
https://www.ncbi.nlm.nih.gov/pubmed/33815656
http://dx.doi.org/10.1155/2021/6653790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987459/
https://www.ncbi.nlm.nih.gov/pubmed/33815656
http://dx.doi.org/10.1155/2021/6653790

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