Cargando…

H(2)O(2)-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways

Mn(III) ortho-N-alkyl- and N-alkoxyalkyl porphyrins (MnPs) were initially developed as superoxide dismutase (SOD) mimics. These compounds were later shown to react with numerous reactive species (such as ONOO(−), H(2)O(2), H(2)S, CO(3)(•-), ascorbate, and GSH). Moreover, the ability of MnPs to oxida...

Descripción completa

Detalles Bibliográficos
Autores principales:	Batinic-Haberle, Ines, Tovmasyan, Artak, Huang, Zhiqing, Duan, Weina, Du, Li, Siamakpour-Reihani, Sharareh, Cao, Zhipeng, Sheng, Huaxin, Spasojevic, Ivan, Alvarez Secord, Angeles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987459/ https://www.ncbi.nlm.nih.gov/pubmed/33815656 http://dx.doi.org/10.1155/2021/6653790

Ejemplares similares

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H(2)O(2)-driven pathways
por: Batinic-Haberle, Ines, et al.
Publicado: (2015)

Corrigendum to ‘An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H(2)O(2)-driven pathways’ [Redox Biology 5C (2015) 43–65]
por: Batinic-Haberle, Ines, et al.
Publicado: (2015)

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes
por: Hasan, Bader, et al.
Publicado: (2021)

Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators
por: Tovmasyan, Artak, et al.
Publicado: (2013)

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP(5+), Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line
por: Chaiswing, Luksana, et al.
Publicado: (2022)

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP(4+), in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H(2)O)MnTnHex-2-PyP(5+)
por: Li, Litao, et al.
Publicado: (2020)

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications()
por: Ali, Dana K., et al.
Publicado: (2013)

Antibacterial Activity of Synthetic Cationic Iron Porphyrins
por: Tovmasyan, Artak, et al.
Publicado: (2020)

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP(5+)
por: Leu, David, et al.
Publicado: (2017)

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae
por: Li, Alice Ma, et al.
Publicado: (2014)

Rational Design of Superoxide Dismutase (SOD) Mimics: The Evaluation of the Therapeutic Potential of New Cationic Mn Porphyrins with Linear and Cyclic Substituents
por: Tovmasyan, Artak, et al.
Publicado: (2014)

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+)()
por: Gauter-Fleckenstein, Benjamin, et al.
Publicado: (2014)

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum()
por: Archambeau, John O., et al.
Publicado: (2013)

Thiol regulation by Mn porphyrins, commonly known as SOD mimics
por: Batinic-Haberle, Ines, et al.
Publicado: (2019)

Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats
por: Wang, Peng, et al.
Publicado: (2022)

Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP(5+), following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats
por: Li, Xuan, et al.
Publicado: (2023)

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance
por: Al-Mutairi, Rawan, et al.
Publicado: (2018)

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP(5+) Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis
por: Anselmo, Wanda, et al.
Publicado: (2018)

Post-illumination cellular effects of photodynamic treatment
por: Charara, Malak, et al.
Publicado: (2017)

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP(5+), Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation
por: Cline, John Mark, et al.
Publicado: (2018)

Mn(III) Porphyrin, MnTnBuOE-2-PyP(5+), Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress
por: Sharma, Sudha, et al.
Publicado: (2023)

Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy
por: Boss, M. K., et al.
Publicado: (2017)

Targeting Mitochondria by Zn(II)N-Alkylpyridylporphyrins: The Impact of Compound Sub-Mitochondrial Partition on Cell Respiration and Overall Photodynamic Efficacy
por: Odeh, Ahmad M., et al.
Publicado: (2014)

The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP(5+), Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin
por: Soares, Rita B., et al.
Publicado: (2023)

The manganese(III) porphyrin MnTnHex-2-PyP(5+) modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
por: Flórido, Ana, et al.
Publicado: (2018)

MnTnHex-2-PyP(5+) Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
por: Soares, Rita B., et al.
Publicado: (2022)

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning
por: Sidlauskaite, Eva, et al.
Publicado: (2018)

Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion
por: MacKinney, Anson, et al.
Publicado: (2019)

Effects of Manganese Porphyrins on Cellular Sulfur Metabolism
por: Olson, Kenneth R., et al.
Publicado: (2020)

The SOD Mimic MnTnHex-2-PyP(5+) Reduces the Viability and Migration of 786-O Human Renal Cancer Cells
por: Costa, João G., et al.
Publicado: (2019)

Ortho Isomeric Mn(III) N-Alkyl- and Alkoxyalkylpyridylporphyrins—Enhancers of Hyaluronan Degradation Induced by Ascorbate and Cupric Ions †
por: Valachová, Katarína, et al.
Publicado: (2021)

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines
por: Davidson, Brittany Anne, et al.
Publicado: (2014)

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management
por: Bellot, Gregory Lucien, et al.
Publicado: (2018)

Manganese Porphyrin-Based SOD Mimetics Produce Polysulfides from Hydrogen Sulfide
por: Olson, Kenneth R., et al.
Publicado: (2019)

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations
por: Jin, Genglin, et al.
Publicado: (2011)

MnTnHex-2-PyP(5+), Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways
por: Shin, Sung-Won, et al.
Publicado: (2021)

Simultaneous determination of LY3214996, abemaciclib, and M2 and M20 metabolites in human plasma, cerebrospinal fluid, and brain tumor by LC-MS/MS
por: Margaryan, Tigran, et al.
Publicado: (2022)

The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus
por: Siamakpour-Reihani, Sharareh, et al.
Publicado: (2011)

Microwave-assisted synthesis of [(52)Mn]Mn-porphyrins: Applications in cell and liposome radiolabelling
por: Gawne, Peter J., et al.
Publicado: (2022)

Radioprotective and tumor antiangiogenic effect of the novel synthetic superoxide dismutase (SOD) mimetic compounds
por: Vujaskovic, Z, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_rgcvv7l20j7hevg226gfh7lclj