Cargando…

Homocysteine-induced decrease in HUVEC cells’ resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism

PURPOSE: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases and also promotes neuronal death in various neurodegenerative diseases. There is evidence that iron can mediate homocysteine (Hcy) toxicity. Thus, the aim of this study was to investigate the effect of Hcy on iro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borkowska, Andzelika, Ziolkowski, Wieslaw, Kaczor, Katarzyna, Herman-Antosiewicz, Anna, Knap, Narcyz, Wronska, Agata, Antosiewicz, Jedrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987610/ https://www.ncbi.nlm.nih.gov/pubmed/32794021 http://dx.doi.org/10.1007/s00394-020-02360-8

Ejemplares similares

hmSOD1 gene mutation‐induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway
por: Halon‐Golabek, Malgorzata, et al.
Publicado: (2018)

Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc
por: Borkowska, Andzelika, et al.
Publicado: (2011)

Iron Metabolism of the Skeletal Muscle and Neurodegeneration
por: Halon-Golabek, Malgorzata, et al.
Publicado: (2019)

JNK/p66Shc/ITCH Signaling Pathway Mediates Angiotensin II-induced Ferritin Degradation and Labile Iron Pool Increase
por: Borkowska, Andżelika, et al.
Publicado: (2020)

Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men
por: Borkowska, Andżelika, et al.
Publicado: (2021)

Sulforaphane inhibits growth of phenotypically different breast cancer cells
por: Pawlik, Anna, et al.
Publicado: (2013)

Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent
por: Tomczyk, Maja, et al.
Publicado: (2020)

Effect of Ischemic Preconditioning on Marathon-Induced Changes in Serum Exerkine Levels and Inflammation
por: Mieszkowski, Jan, et al.
Publicado: (2020)

HFE Gene Mutations and Iron Status in 100 Healthy Polish Children
por: Kaczorowska-Hac, Barbara, et al.
Publicado: (2017)

The impact of H63D HFE gene carriage on hemoglobin and iron status in children
por: Barbara, Kaczorowska-Hac, et al.
Publicado: (2016)

Swim training affects Akt signaling and ameliorates loss of skeletal muscle mass in a mouse model of amyotrophic lateral sclerosis
por: Cieminski, Karol, et al.
Publicado: (2021)

Ferritin Genes Overexpression in PBMC and a Rise in Exercise Performance as an Adaptive Response to Ischaemic Preconditioning in Young Men
por: Mieszkowski, Jan, et al.
Publicado: (2019)

Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice
por: Flis, Damian Jozef, et al.
Publicado: (2018)

Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis
por: Cieminski, Karol, et al.
Publicado: (2022)

Vitamin D Supplementation and Nordic Walking Training Decreases Serum Homocysteine and Ferritin in Elderly Women
por: Walentukiewicz, Anna, et al.
Publicado: (2018)

Swim Training Modulates Mouse Skeletal Muscle Energy Metabolism and Ameliorates Reduction in Grip Strength in a Mouse Model of Amyotrophic Lateral Sclerosis
por: Flis, Damian Jozef, et al.
Publicado: (2019)

Fasting and Exercise Induce Changes in Serum Vitamin D Metabolites in Healthy Men
por: Żychowska, Małgorzata, et al.
Publicado: (2021)

Changes in Serum Iron and Leukocyte mRNA Levels of Genes Involved in Iron Metabolism in Amateur Marathon Runners—Effect of the Running Pace
por: Grzybkowska, Agata, et al.
Publicado: (2019)

Eight-Day Fast and a Single Bout of Exercise: The Effect on Serum Methylarginines and Amino Acids in Men
por: Reczkowicz, Joanna, et al.
Publicado: (2023)

Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants
por: Pawlik, Anna, et al.
Publicado: (2015)

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
por: Mieszkowski, Jan, et al.
Publicado: (2021)

Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
por: Kortas, Jakub, et al.
Publicado: (2020)

Exercise-Induced Changes in Caveolin-1, Depletion of Mitochondrial Cholesterol, and the Inhibition of Mitochondrial Swelling in Rat Skeletal Muscle but Not in the Liver
por: Flis, Damian Jozef, et al.
Publicado: (2016)

Erratum to: Sulforaphane inhibits growth of phenotypically different breast cancer cells
por: Pawlik, Anna, et al.
Publicado: (2013)

Autophagy in homocysteine‑induced HUVEC senescence
por: Zhang, Yexi, et al.
Publicado: (2023)

New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential
por: Pacuła, Agata J., et al.
Publicado: (2017)

Remote Ischemic Preconditioning Reduces Marathon-Induced Oxidative Stress and Decreases Liver and Heart Injury Markers in the Serum
por: Mieszkowski, Jan, et al.
Publicado: (2021)

Mechanism of selective anticancer activity of isothiocyanates relies on differences in DNA damage repair between cancer and healthy cells
por: Hać, Aleksandra, et al.
Publicado: (2019)

Effect of Nordic Walking training on iron metabolism in elderly women
por: Kortas, Jakub, et al.
Publicado: (2015)

In Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues
por: Kaczor-Keller, Katarzyna B., et al.
Publicado: (2020)

Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training
por: Kortas, Jakub, et al.
Publicado: (2020)

Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain
por: Dzik, Katarzyna Patrycja, et al.
Publicado: (2019)

Vitamin D Supplementation Improves the Effects of the Rehabilitation Program on Balance and Pressure Distribution in Patients after Anterior Cervical Interbody Fusion-Randomized Control Trial
por: Skrobot, Wojciech, et al.
Publicado: (2020)

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment
por: Flis, Damian Jozef, et al.
Publicado: (2022)

Identification of Optimal Reference Genes for qRT-PCR Normalization for Physical Activity Intervention and Omega-3 Fatty Acids Supplementation in Humans
por: Grzybkowska, Agata, et al.
Publicado: (2023)

Nordic Walking Training Causes a Decrease in Blood Cholesterol in Elderly Women Supplemented with Vitamin D
por: Prusik, Krzysztof, et al.
Publicado: (2018)

Planned Physical Workload in Young Tennis Players Induces Changes in Iron Indicator Levels but Does Not Cause Overreaching
por: Żurek, Piotr, et al.
Publicado: (2022)

The Effect of a Six-Week Nordic Walking Training Cycle on Oxidative Damage of Macromolecules and Iron Metabolism in Older Patients with Multiple Myeloma in Remission—Randomized Clinical Trial
por: Czerwińska-Ledwig, Olga, et al.
Publicado: (2023)

Nordic walking training attenuation of oxidative stress in association with a drop in body iron stores in elderly women
por: Kortas, Jakub, et al.
Publicado: (2017)

Early Rehabilitation Program and Vitamin D Supplementation Improves Sensitivity of Balance and the Postural Control in Patients after Posterior Lumbar Interbody Fusion: A Randomized Trial
por: Skrobot, Wojciech, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ih1tqgujhtue8oce0ivrp0u614