G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease

DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats can form stable single-stranded secondary structures, called G-quadruplexes (G4). Herein, we report that the Polycomb group protein BMI1 is enriched at heterochromatin regions containing putative G4 DNA sequences...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanna, Roy, Flamier, Anthony, Barabino, Andrea, Bernier, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987966/
https://www.ncbi.nlm.nih.gov/pubmed/33758195
http://dx.doi.org/10.1038/s41467-021-22129-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987966/
https://www.ncbi.nlm.nih.gov/pubmed/33758195
http://dx.doi.org/10.1038/s41467-021-22129-9

Ejemplares similares