Efficacy of combination treatment using YHO-1701, an orally active STAT3 inhibitor, with molecular-targeted agents on cancer cell lines

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell growth, survival, and metastasis. STAT3 signaling is constitutively activated in various types of hematologic or solid malignancies. YHO-1701 has been developed as an orally available STAT3 inhibitor....

Descripción completa

Detalles Bibliográficos
Autores principales: Taniguchi, Keisuke, Konishi, Hiroaki, Yoshinaga, Akiko, Tsugane, Momomi, Takahashi, Hiroyuki, Nishisaka, Fukiko, Shishido, Yoshiyuki, Asai, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988006/
https://www.ncbi.nlm.nih.gov/pubmed/33758275
http://dx.doi.org/10.1038/s41598-021-86021-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988006/
https://www.ncbi.nlm.nih.gov/pubmed/33758275
http://dx.doi.org/10.1038/s41598-021-86021-8

Ejemplares similares