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Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
Increased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D), but mechanisms underlying this pathogenic inter-organ crosstalk are incompletely understood. We find PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2), recently identified as the Akt Ser473 pho...
Autores principales: | Kim, KyeongJin, Kang, Jin Ku, Jung, Young Hoon, Lee, Sang Bae, Rametta, Raffaela, Dongiovanni, Paola, Valenti, Luca, Pajvani, Utpal B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988046/ https://www.ncbi.nlm.nih.gov/pubmed/33758172 http://dx.doi.org/10.1038/s41467-021-22106-2 |
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