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Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
Immunoglobulin repertoires contain a fraction of antibodies that recognize low molecular weight compounds, including some enzymes’ cofactors, such as heme. Here, by using a set of 113 samples with variable region sequences matching clinical-stage antibodies, we demonstrated that a considerable numbe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988133/ https://www.ncbi.nlm.nih.gov/pubmed/33758329 http://dx.doi.org/10.1038/s42003-021-01931-7 |