Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). LAT1 is overexpressed in many types of tumors and mediates the transfer of drugs and hormones across the blood-brain barrier. Thu...

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Detalles Bibliográficos
Autores principales: Yan, Renhong, Li, Yaning, Müller, Jennifer, Zhang, Yuanyuan, Singer, Simon, Xia, Lu, Zhong, Xinyue, Gertsch, Jürg, Altmann, Karl-Heinz, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988154/
https://www.ncbi.nlm.nih.gov/pubmed/33758168
http://dx.doi.org/10.1038/s41421-021-00247-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988154/
https://www.ncbi.nlm.nih.gov/pubmed/33758168
http://dx.doi.org/10.1038/s41421-021-00247-4

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