Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product

Coagulation factor IX (FIX) is a complex post-translationally modified human serum glycoprotein and high-value biopharmaceutical. The quality of recombinant FIX (rFIX), especially complete γ-carboxylation, is critical for rFIX clinical efficacy. Bioreactor operating conditions can impact rFIX produc...

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Detalles Bibliográficos
Autores principales: Zacchi, Lucia F., Roche-Recinos, Dinora, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L., Howard, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988164/
https://www.ncbi.nlm.nih.gov/pubmed/33758337
http://dx.doi.org/10.1038/s42003-021-01903-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988164/
https://www.ncbi.nlm.nih.gov/pubmed/33758337
http://dx.doi.org/10.1038/s42003-021-01903-x

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