Generation of FX (−/−) and Gmds (−/−) CHOZN host cell lines for the production of afucosylated therapeutic antibodies

Antibody‐dependent cellular cytotoxicity (ADCC) is the primary mechanism of actions for several marketed therapeutic antibodies (mAbs) and for many more in clinical trials. The ADCC efficacy is highly dependent on the ability of therapeutic mAbs to recruit effector cells such as natural killer cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Weiyi, Padmashali, Roshan, Monzon, Omar Quintero, Lundberg, Dianna, Jin, Shan, Dwyer, Brian, Lee, Yun‐Jung, Korde, Anisha, Park, Sophia, Pan, Clark, Zhang, Bohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988551/
https://www.ncbi.nlm.nih.gov/pubmed/32748555
http://dx.doi.org/10.1002/btpr.3061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988551/
https://www.ncbi.nlm.nih.gov/pubmed/32748555
http://dx.doi.org/10.1002/btpr.3061

Ejemplares similares