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Generation of FX (−/−) and Gmds (−/−) CHOZN host cell lines for the production of afucosylated therapeutic antibodies
Antibody‐dependent cellular cytotoxicity (ADCC) is the primary mechanism of actions for several marketed therapeutic antibodies (mAbs) and for many more in clinical trials. The ADCC efficacy is highly dependent on the ability of therapeutic mAbs to recruit effector cells such as natural killer cells...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988551/ https://www.ncbi.nlm.nih.gov/pubmed/32748555 http://dx.doi.org/10.1002/btpr.3061 |