Cargando…

Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses

Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Hong, Rao, Aditya M., Dermadi, Denis, Toh, Jiaying, Murphy Jones, Lara, Donato, Michele, Liu, Yiran, Su, Yapeng, Dai, Cheng L., Kornilov, Sergey A., Karagiannis, Minas, Marantos, Theodoros, Hasin-Brumshtein, Yehudit, He, Yudong D., Giamarellos-Bourboulis, Evangelos J., Heath, James R., Khatri, Purvesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988739/ https://www.ncbi.nlm.nih.gov/pubmed/33765435 http://dx.doi.org/10.1016/j.immuni.2021.03.002

Ejemplares similares

A Multi-mRNA Prognostic Signature for Anti-TNFα Therapy Response in Patients with Inflammatory Bowel Disease
por: Sakaram, Suraj, et al.
Publicado: (2021)

A robust gene expression signature for NASH in liver expression data
por: Hasin-Brumshtein, Yehudit, et al.
Publicado: (2022)

A machine learning classifier using 33 host immune response mRNAs accurately distinguishes viral and non-viral acute respiratory illnesses in nasal swab samples
por: Pandya, Rushika, et al.
Publicado: (2023)

Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections
por: Thair, Simone A., et al.
Publicado: (2020)

521. Similarities and Differences in Transcriptomic Host Response between SARS-CoV-2 and Other Viral Infections
por: Thair, Simone A, et al.
Publicado: (2020)

Inferring direction of associations between histone modifications using a neural processes-based framework
por: Ganesan, Ananthakrishnan, et al.
Publicado: (2022)

Detrimental effect of apoptosis of lymphocytes at an early time point of experimental abdominal sepsis
por: Atmatzidis, Stefanos, et al.
Publicado: (2011)

A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections
por: Buturovic, Ljubomir, et al.
Publicado: (2022)

Editorial Introduction to the Supplement “Diagnosis of Infectious Diseases by Detection of Microbial Pathogens: A Joint Session Between HemoSpec FrameWork 7 Consortium with COST Action BM1401 Raman4Clinics Working Group 2”
por: Giamarellos-Bourboulis, Evangelos J.
Publicado: (2018)

Complex immune deregulation in severe COVID-19: More than a mechanism of pathogenesis
por: Giamarellos-Bourboulis, Evangelos J.
Publicado: (2021)

Allele-specific expression and eQTL analysis in mouse adipose tissue
por: Hasin-Brumshtein, Yehudit, et al.
Publicado: (2014)

Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression
por: Link, Jenny C., et al.
Publicado: (2017)

The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host
por: Christaki, Eirini, et al.
Publicado: (2014)

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis
por: Karakike, Eleni, et al.
Publicado: (2019)

Antimicrobial Stewardship Using Biomarkers: Accumulating Evidence for the Critically Ill
por: Kyriazopoulou, Evdoxia, et al.
Publicado: (2022)

Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study
por: Bacharaki, Dimitra, et al.
Publicado: (2023)

Obesity as a Consequence of Gut Bacteria and Diet Interactions
por: Kotzampassi, Katerina, et al.
Publicado: (2014)

Reply to Radermacher et al. on “Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus”
por: Renieris, Georgios, et al.
Publicado: (2021)

Mass-Cytometry-Based Quantification of Global Histone Post-Translational Modifications at Single-Cell Resolution Across Peripheral Immune Cells in IBD
por: Bai, Lawrence, et al.
Publicado: (2022)

In Vitro Activity of Oral Cephalosporins (Cefprozil and Cefixime) Against Ciprofloxacin-Resistant Enterobacteriaceae from Community-Acquired Urinary-Tract Infections
por: Pistiki, Aikaterini, et al.
Publicado: (2015)

Sepsis: Diagnostic and Therapeutic Challenges
por: Molnár, Zsolt, et al.
Publicado: (2016)

Monkeypox: A real new warning or just a sign of times?
por: Georgiadou, Sara P., et al.
Publicado: (2023)

Multi-omics approaches to disease
por: Hasin, Yehudit, et al.
Publicado: (2017)

Observational evidence for detrimental impact of inhaled ozone on human respiratory system
por: Lu, Jiaying, et al.
Publicado: (2023)

Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage
por: Giamarellos-Bourboulis, Evangelos J., et al.
Publicado: (2016)

Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
por: Rizos, Evripidis, et al.
Publicado: (2022)

Clarithromycin is an effective immunomodulator when administered late in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa
por: Giamarellos-Bourboulis, Evangelos J, et al.
Publicado: (2006)

Increases in inflammatory and CD14(dim)/CD16(pos)/CD45(pos) patrolling monocytes in sepsis: correlation with final outcome
por: Gainaru, Gabriela, et al.
Publicado: (2018)

Correction: Sepsis, a call for inclusion in the work plan of the European Center for Disease Prevention and Control
por: Giamarellos-Bourboulis, Evangelos J., et al.
Publicado: (2023)

Sepsis, a call for inclusion in the work plan of the European Center for Disease Prevention and Control
por: Giamarellos-Bourboulis, Evangelos J., et al.
Publicado: (2023)

Coupling of Physiological and Proteomic Analysis to Understand the Ethylene- and Chilling-Induced Kiwifruit Ripening Syndrome
por: Minas, Ioannis S., et al.
Publicado: (2016)

Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection
por: Tsaganos, Thomas, et al.
Publicado: (2016)

The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort
por: Karakike, Eleni, et al.
Publicado: (2019)

Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study
por: Goumenos, Stavros, et al.
Publicado: (2020)

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia
por: Rovina, Nikoletta, et al.
Publicado: (2020)

Soluble fms-like tyrosine kinase 1, placental growth factor and procalcitonin as biomarkers of gram-negative sepsis: Analysis through a derivation and a validation cohort
por: Vittoros, Vasileios, et al.
Publicado: (2021)

Early life immunity in the era of systems biology: understanding development and disease
por: Schaffert, Steven, et al.
Publicado: (2018)

The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators
por: Kyriakopoulou, Magdalini, et al.
Publicado: (2008)

Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: results from an observational study
por: Pelekanou, Aimilia, et al.
Publicado: (2009)

Association between genotypes of rs34436714 of NLRP12 and serum tumor necrosis factor-alpha in inflammatory bowel disease: A case-control study
por: Dellaporta, Erminia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eovdb0mtbdckp15hv0cth1p1pg