An (111)In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells

Theranostic radionuclides that emit Auger electrons (AE) can generate highly localised DNA damage and the accompanying gamma ray emission can be used for single-photon emission computed tomography (SPECT) imaging. Mismatched DNA base pairs (mismatches) are DNA lesions that are abundant in cells defi...

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Detalles Bibliográficos
Autores principales: Gill, Martin R., Walker, Michael G., Able, Sarah, Tietz, Ole, Lakshminarayanan, Abirami, Anderson, Rachel, Chalk, Rod, El-Sagheer, Afaf H., Brown, Tom, Thomas, Jim A., Vallis, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989384/
https://www.ncbi.nlm.nih.gov/pubmed/33815738
http://dx.doi.org/10.1039/d0sc02825h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989384/
https://www.ncbi.nlm.nih.gov/pubmed/33815738
http://dx.doi.org/10.1039/d0sc02825h

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