Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders

TMEM106B is a transmembrane protein localized to the endo-lysosomal compartment. Genome-wide association studies have identified TMEM106B as a risk modifier of Alzheimer’s disease and frontotemporal lobar degeneration, especially with progranulin haploinsufficiency. We recently demonstrated that TME...

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Detalles Bibliográficos
Autores principales: Perez-Canamas, Azucena, Takahashi, Hideyuki, Lindborg, Jane A, Strittmatter, Stephen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990118/
https://www.ncbi.nlm.nih.gov/pubmed/33796852
http://dx.doi.org/10.1093/braincomms/fcaa200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990118/
https://www.ncbi.nlm.nih.gov/pubmed/33796852
http://dx.doi.org/10.1093/braincomms/fcaa200

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