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Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders
TMEM106B is a transmembrane protein localized to the endo-lysosomal compartment. Genome-wide association studies have identified TMEM106B as a risk modifier of Alzheimer’s disease and frontotemporal lobar degeneration, especially with progranulin haploinsufficiency. We recently demonstrated that TME...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990118/ https://www.ncbi.nlm.nih.gov/pubmed/33796852 http://dx.doi.org/10.1093/braincomms/fcaa200 |