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Therapeutic targeting of tumor hypoxia and necrosis with antibody α-radioconjugates
Solid tumors are inherently difficult to treat because of large regions of hypoxia and are often chemotherapy- or radiotherapy-resistant. It seems that cancer stem cells reside in hypoxic and adjacent necrotic tumor areas. Therefore, new treatments that are highly selective for tumors and can eradic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990135/ https://www.ncbi.nlm.nih.gov/pubmed/30406213 http://dx.doi.org/10.1093/abt/tby010 |